NFKBIA and gastroesophageal reflux disease: Furthermore, the anti-inflammatory effects of RC-mix suggested that the inactivation of NF-κB by blocking the phosphorylation of IκBα led to the inhibition of the release of proinflammatory cytokines and mediators, reducing the inflammatory damage that is typical in the esophageal mucosa of rats with reflux esophagitis (Figure 8).