In the present study, the objective, using the classical septic model, that is, CLP, is to investigate the impact of sepsis on the expression of Nrp-1 on CD4+CD25+Tregs and the negative immunoregulation of Nrp-1highCD4+CD25+Tregs in septic mice, as well as the potential therapeutic value of Nrp-1 in sepsis. This evidence concerns the gene CD4 and Sepsis.