In the current study, we found that recombinant Nrp-1 polyclonal antibody could downregulate the demethylation of Foxp-3-TSDR in the presence of LPS; thus, Nrp-1 could represent a new potential therapeutic target, at least via regulating the stability of Tregs, for the study of immune regulation in sepsis. The gene discussed is FOXP3; the disease is Sepsis.