CD4 and Sepsis: In the present study, the results suggested that Nrp-1highCD4+CD25+Tregs had the strongest ability to inhibit the proliferation and increase the apoptosis, as well as inhibiting the cytokine secretion of CD4+CD25− T cells, but Nrp-1lowCD4+CD25+Tregs had opposed ability on CD4+CD25− T cells; thus, we conjectured that Nrp-1lowCD4+CD25+Tregs had a potential ability to prevent cellular immunosuppression in sepsis.