Solomon and his colleagues further showed that Nrp-1+CD4+CD25+Tregs suppressed the proliferation of CD4+CD25− T cell more efficiently than CD4+CD25+Tregs and Nrp-1−CD4+CD25+Tregs in a mouse model of experimental autoimmune encephalomyelitis (EAE) [25]. Here, CD4 is linked to experimental autoimmune encephalomyelitis.