NRP1 and Sepsis: As shown in Figures 1(a) and 1(e), CD4+CD25+Tregs were isolated from spleens at 24 hours after CLP, and it was found that, compared with the control group, expressions of Nrp-1 and Foxp-3 of CD4+CD25+Tregs were significantly promoted by sepsis (P < 0.01).