INS and obesity due to melanocortin 4 receptor deficiency: Lean individuals presented lower levels of glucose, insulin, and HOMA-IR when compared with individuals with and without IR, whereas NEFA presented no changes in different groups (Figure 1(c)); lean individuals showed lower levels of triglycerides and LDLc compared to subjects with and without IR, also lean individuals presented lower levels of total cholesterol and VLDLc when compared to obesity group with IR.