Given the compelling documentary evidence for abnormal cortical organization (Stoner et al., 2014) and defective neuronal positioning (Wegiel et al., 2010) in children diagnosed with autism, our findings are consistent with the notion that certain clinical presentations of autism spectrum disorder could be delineated on the basis of candidate gene mutations, including to DENR, which disrupt core signaling pathways for neural circuit organization and synaptic function (Liu et al., 2014, Neale et al., 2012). This evidence concerns the gene DENR and autism spectrum disorder.