RYR2 and catecholaminergic polymorphic ventricular tachycardia: The present investigations, which corroborates previous work by Bannister and colleagues (Bannister et al., 2015), present the unequivocal demonstration that flecainide does not have a direct effect on luminal‐to‐cytosolic Ca2+ flux through RyR2 channels, and fundamentally challenges reports that flecainide efficacy in RyR2 channel‐ and CSQ‐mutation linked CPVT patients is due to an additive effect of INa inhibition and a direct block of RyR2 channels (Watanabe et al., 2009; Hilliard et al., 2010; Galimberti and Knollmann, 2011; Hwang et al., 2011; Lee et al., 2012).