Because neuropathologically validated schwannoma-like growth only occurred in crushed nerves of mice bearing deletion of one nf2 allele in both glial and neuronal compartments of peripheral nerves (P0-Cre;Nefh-Cre;Nf2fl/+), we hypothesized that LOH of the nf2 gene is dispensable for tumor initiation. Here, NF2 is linked to schwannoma.