SARS2 and familial primary hypomagnesemia: At least three distinct mitochondrial syndromes are accompanied by hypomagnesemia: (1) deletions in the mitochondrial genome as seen in Kearns–Sayre syndrome [62] (2) recessive mutations in the human gene SARS2 [57] and (3) mutations in the mitochondrial tRNAIle gene MT-TI causing a syndrome with hypertension, hypercholesterolemia and hypomagnesemia [56].