Concerns over primaquine dose-dependent haemolytic effects in persons with glucose-6-phosphate dehydrogenase (G6PD) [60] are allayed by recent WHO guidelines that indicate that a single primaquine dose (0.25 mg base/kg) concomitantly administered on the first day of ACT treatment, is both effective in blocking transmission and unlikely to cause serious toxicity in individuals with any of the G6PD-deficiency variants, obviating the need for systematic and onerous G6PD testing [59, 61, 62]. This evidence concerns the gene G6PD and hyperinsulinemic hypoglycemia, familial, 4.