The ratios of Tregs:pDCs (Fig. 1d, p = 0.02), activated Tregs:pDCs (Fig. 1e, p = 0.01) and FoxP3+ CD4+ T-cells:pDCs (Fig. 1f, p = 0.01) were also higher in tumor stage 2, 3, 4. This evidence concerns the gene FOXP3 and neoplasm.