Germline Sufu mutations have been identified in medulloblastoma (Taylor et al, 2002; Kool et al, 2014) and associated with the development of medulloblastoma in Gorlin syndrome (Pastorino et al, 2009; Kijima et al, 2012; Smith et al, 2014). The gene discussed is SUFU; the disease is medulloblastoma.