Polβ mRNA was significantly higher in the cerebellum of AD patients (p <0.00001) than in the same brain region in healthy controls (Fig. 2b, Table 1) and PARP1 mRNA was significantly lower in AD cerebellum (p < 0.0005) compared to HC cerebellum and significantly higher in AD hippocampus (p < 0.005) and entorhinal cortex (p < 0.0001) compared to the same regions in HC (Fig. 2c, Table 1). Here, PARP1 is linked to Alzheimer disease.