Particularly, Polβ mRNA was significantly different between cerebellum and hippocampus (p < 0.00005) and entorhinal cortex (p <0.001) and frontal cortex (p <0.01) within AD patients and between cerebellum and hippocampus (p <0.01), entorhinal cortex (p <0.005) and frontal cortex (p <0.005) within HC (Fig. 2b, Table 2). This evidence concerns the gene POLB and Alzheimer disease.