To explore the relations between BER and the pathological features of AD, we compared the BER mRNA profile in blood in individuals exhibiting 1) only high Aβ-42 (n = 19), 2) only low P-tau or high T-tau or both (referred to as abnormal tau from here on) (n = 24), 3) both high Aβ-42 and abnormal tau (n = 29) levels in CSF exceeding cut-off levels (see Additional file 1: Table S3), and 4) patients with normal levels of CSF Aβ-42 and tau (n = 64) and 5) HC (n = 28) displaying normal CSF levels of CSF Aβ-42 and tau. Here, MAPT is linked to Alzheimer disease.