Beclin-1 is a key component of autophagy and microtubule-associated protein 1 light chain (LC3) is a good indicator of autophagy [9]; however, the extent of their involvement in the occurrence and progression of CTEPH vascular endothelial lesions through the regulation of autophagic capacity remains unclear [8]. This evidence concerns the gene BECN1 and chronic thromboembolic pulmonary hypertension.