ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Another study showed that some alkyne-containing pyrazolopyrimidines can inhibit not only Abl(T315I) in vitro but also Bcr-Abl(T315I) in cells, suggesting that these pyrazolopyrimidines can serve as lead compounds for targeted therapy to overcome drug resistance of CML [191].