IKZF1 and acute myeloid leukemia: However, in Ph-positive B-ALL, AML, MPAL, and CML-AP and CML-BP, deletions involving immunoglobulin heavy chain (IGH), T-cell receptor (TCR), encoding the transcription factor IKAROS family zinc finger protein 1 (IKZF1), and cyclin-dependent kinase inhibitor 2 (CDKN2A/B) are common [66].