2010). These conditions are not coincident with those observed in general metabolic disorders like hyperlipidemia and diabetes, indicating that aging and such diseases have different pathophysiological feature. Thus, the impact of aging on vascular system might be not exactly the same as that of metabolic disorders. As a matter of fact, diabetes has been demonstrated to disrupt the sGC redox equilibrium in the vasculature (Stasch et al. 2006; Goulopoulou et al. 2015), which is contrasted with the present findings about aging. The gene discussed is SGCB; the disease is metabolic disease.