Notch-1 is a homolog of the translocation-associated Notch homologue (TAN-1) discovered in the t(7;9)(q34;q34) translocation in some T-cell acute lymphoblastic leukemia patients (T-ALL) [3]; its ligands are modified by a protein O-fucosyltransferase 1 (POFUT1) that attaches L-fucose to a serine or threonine within EGF domains [4, 5]. The gene discussed is NOTCH1; the disease is T-cell acute lymphoblastic leukemia.