TP53 and Familial prostate cancer: Since the p53 signaling pathway is a main target of resveratrol, and because 3 overlapping genes (PTEN, TP53 and CDKN1A) were also found to be associated with prostate cancer by KEGG analysis embedded in WebGestalt, we utilized the 3 indicated overlapping genes identified in both p53 signaling and KEGG pathways to cross check their cancer genomic alterations and clinical profiles in prostate cancer (Table 3).