Since the p53 signaling pathway is a main target of resveratrol, and because 3 overlapping genes (PTEN, TP53 and CDKN1A) were also found to be associated with prostate cancer by KEGG analysis embedded in WebGestalt, we utilized the 3 indicated overlapping genes identified in both p53 signaling and KEGG pathways to cross check their cancer genomic alterations and clinical profiles in prostate cancer (Table 3). This evidence concerns the gene PTEN and Familial prostate cancer.