VCAM1 and plasma cell myeloma: It is the first time where circulating levels of an adhesion molecule independently correlate with survival in myeloma patients and this confirms preclinical findings where VCAM-1 seems to have an important role in the myeloma cell growth and progression.5, 18 Especially, in the B9/BM1 syngeneic murine bone marrow myeloma model, the myeloma cell growth was based on VCAM-1 and was completely suppressed by an anti-VCAM-1 monoclonal antibody.