VCAM-1 protein is an endothelial ligand for very late antigen-4 (VLA-4 or α4β1) of the β1 subfamily of integrins and is implicated in the homing and migration of malignant cells, including MM cells.4, 5 ICAM-1 is an intracellular adhesion molecule expressed on the membrane of leukocytes and on endothelial cells. The gene discussed is VCAM1; the disease is Miyoshi myopathy.