Adhesion molecules such as VCAM-1, ICAM-1 and selectins mediate the homing of MM cells to the BM and are implicated in the MM cell growth and survival.1, 2, 3, 15 There is very limited information in the literature regarding the circulating levels of adhesion molecules in myeloma patients and their significance. The gene discussed is ICAM1; the disease is Miyoshi myopathy.