Thus, the aim of this prospective study was to evaluate the circulating levels of VCAM-1, ICAM-1, P-, L- and E-selectin in myeloma patients, to explore possible correlation with disease characteristics, including survival and to investigate the effect of anti-myeloma agents, such as bortezomib and lenalidomide, on their levels. This evidence concerns the gene SELE and plasma cell myeloma.