Since pre-clinical studies have confirmed that resveratrol can induce the expression of NKG2D ligands in transformed cells and thus render these cells more susceptible to NK cell lysis via NKG2D cytotoxic pathways [22], this study suggested that resveratrol may modulate this axis to allow for increased tumor surveillance by the innate immune system [22]. This evidence concerns the gene KLRK1 and neoplasm.