Firstly, one study investigated the effects of resveratrol at variable high doses (0.5, 1, 2.5 and 5 grams / day for 29 days; n = 10-12 / dose) on circulating levels of insulin-like growth factor (IGF-1) and IGF-binding protein 3 (IGFBP-3) [47], two markers often associated with increased tumor formation and subsequent metastasis [48]. Here, IGFBP3 is linked to neoplasm.