Only five analytes (TFF3, IGFBP-4, factor VII, myoglobin, and FAS) with significant interactions between sex and log2-transformed analyte concentration in the CMA/control and four (TFF3, B2M, factor VII, and MIP-3B) in the remitted MDD/control comparisons overlapped with the 28 significant analytes in the MDD/control comparisons (see Fig 4 and S5 Table). This evidence concerns the gene IGFBP4 and major depressive disorder.