Five analytes found to differ between MDD patients and controls in the work of Bot et al. (2015) [19] (cystatin-C, FABP (adipocyte), fetuin-A, IGFBP-5, and PPP) were rather found to be sex-dependent markers of MDD in this study, meaning their association with the disorder was different in males and females. The gene discussed is CST3; the disease is major depressive disorder.