MTHFR and steatosis: It has been demonstrated that microsomal triglyceride transfer protein (MTP) polymorphism (493GT) was associated with a higher prevalence of NAFLD in HCV genotype 3 [39]; methylene tetrahydrofolate reductase (MTHFR) polymorphism (C677T) [40] was correlated with an increased prevalence of NAFLD in chronic HCV infections as well as an increased risk to develop severe steatosis (i.e., 6-fold higher for hosts with a MTHFR “CT” genotype and 20-fold higher for those with a “TT” genotype) [40].