However, Moucari et al. [60] evaluated 500 patients with chronic hepatitis C and the multivariate analysis showed that both steatosis (adjusted OD 1.95, 1.24–3.06, p = 0.004) and insulin resistance (adjusted OD: 1.80, 1.15–2.81, p = 0.009) were independently associated with advanced liver fibrosis. This evidence concerns the gene INS and chronic hepatitis C virus infection.