In accordance with our observation, previous studies [3,5,6,7,8] also reported that cardiac Sca-1+/CD31− cells exhibit multipotent differentiation potential in vitro and their therapeutic potential in experimental myocardial infarction models, whereas cardiac Sca-1+/CD31+ cells showed endothelial-like characteristics. The gene discussed is PECAM1; the disease is myocardial infarction.