Ren et al. applied a well-established cardiac ischemia/reperfusion (I/R) model to determine the miRNA expression signature in ischemic hearts, and found that knockdown of endogenous miR-320 provided protection against I/R-induced cardiomyocyte death and apoptosis by targeting a well-studied cardioprotector HSP20 [10]. The gene discussed is HSPB6; the disease is myocardial ischemia.