PARP1 and neoplasm: They were also able to demonstrate the olaparib inhibited PARP in PBMC and tumor tissue although they said that PARP levels were less efficiently inhibited when it was used for a short duration based on their observations that maximum inhibition of PAR was seen between 6 and 24 h after the first dose of administration and that PAR levels had started approaching baseline values within 36 h of the last dose of olaparib and exceeded baseline values in 80 % of cases before the next cycle of treatment [27].