ERBB2 and cervical carcinoma: In a second, larger phase II study, 230 patients, with stage IVb persistent/recurrent cervical carcinoma not amenable to curative therapy and at least one prior regimen in the metastatic setting, were randomly assigned to one of three arms: pazopanib alone, lapatinib (a TKI targeting EGFR and HER2/neu) alone, or a combination of the two agents.