More recently, examination of the fallopian tubes removed at risk-reducing bilateral salpingo-oophorectomy (RRBSO) from women with BRCA1 and BRCA2 mutations revealed the presence in the distal fallopian tube (the fimbriae) of occult/small cancers in 5–15 % of these high-risk women [24–26] and preinvasive lesions in the fimbriae (serous tubal intraepithelial cancers; STICs) in 1–6 % of the women [27–30]. Here, BRCA1 is linked to cancer.