TP53 and clear cell adenocarcinoma: Similar to the other type I Mullerian carcinomas, clear cell carcinomas are not associated with chromosomal instability or mutations in TP53 or BRCA. Notably, clear cell carcinomas of Mullerian origin exhibit distinctive gene expression profiles from other Mullerian histologies, while sharing significant expression patterns with clear cell tumors of the kidney and endometrium [124,125].