As shown in Fig. 6A,B, NKD1 was down-regulated at the mRNA level in HCC tissues compared with non-tumor tissues, whereas Rac1 was up-regulated in HCC tissues, although no difference was found in the Rac1 mRNA level between HCC and non-tumor tissues (Fig. S2). The gene discussed is NKD1; the disease is hepatocellular carcinoma.