FN1 was down-regulated after 5d in AD and MCS, which could be a cause that also kinase insert domain receptor (KDR) gene is down-regulated in AD and MCS, because its gene status is under the positive influence of FN1 as shown in Fig. 4 and described in the literature69, 70, 71, 72, 73. Here, FN1 is linked to Alzheimer disease.