Previous genome-wide association (GWA) studies have identified multiple lung cancer susceptibility loci among individuals of European ancestry11, 12, 13, 14, 15, 16, and two of the identified loci are mapped to the C-reactive protein (CRP) gene and interleukin 1 receptor accessory protein (IL1RAP) gene, respectively. This evidence concerns the gene IL1RAP and lung carcinoma.