From the results of our congenic line analysis, we mapped the genomic intervals associated with resistance to podocyte injury and tubulointerstitial fibrosis in Tns2-deficiet mice, and designated the former locus Tpir, Tns2nph-induced podocyte injury resistance, and the latter locus Ttir, Tns2nph-induced tubulointerstitial fibrosis resistance (Fig. 4). Here, TNS2 is linked to fibrosis.