TREX1 and Retinal vasculopathy and cerebral leukodystrophy: Mutations in TREX1 cause a spectrum of type I IFN-dependent autoinflammatory and autoimmune phenotypes including Aicardi–Goutières syndrome (AGS), familial chilblain lupus, retinal vasculopathy with cerebral leukodystrophy (RVCL) and systemic lupus erythematosus (SLE)5, 6, 7, 8, 9.