Furthermore, the overlap of the sweep peaks with the recombination hotspots in the area downstream of the gene, specifically in an area associated with obesity-related traits and Gaucher disease severity, indicates that the TCF7L2 gene is part of a strongly selected region in which rare variants that survive selective sweep could be genetic sources that modify metabolism. Here, TCF7L2 is linked to obesity due to melanocortin 4 receptor deficiency.