In a sub-study of the ARRIVE (Abatacept Researched in Rheumatoid arthritis patients with an Inadequate anti-TNF response to Validate Effectiveness) trial, 81 and 75 % of abatacept-treated patients with active RA responded to at least one pneumococcal or influenza strain, respectively, demonstrating that patients treated with abatacept are able to mount an immune response to pneumococcal or influenza vaccination [19, 20]. This evidence concerns the gene TNF and rheumatoid arthritis.