To pursue a cause for association between LBP and glycan levels in MZ twins discordant for LBP, we split them into groups of high and low level of IGP65, IGP74, IGP75, and IGP76 using 25% and 75% quintiles as the cut off points and compared the prevalence of systemic inflammatory disorders (rheumatoid arthritis, systemic lupus erythematosus, ulcerative colitis and Crohn’s disease) in these groups. The gene discussed is LBP; the disease is rheumatoid arthritis.