In prediabetes and diabetes conditions, circulating levels of IL1β, IL18, and IL1RA, which are induced by IL1β, are elevated [19, 45], and treatment with IL1β induces insulin resistance in adipocytes, implying that IL1β and IL18 have a crucial role in the development of type 2 diabetes [46]. The gene discussed is IL1R1; the disease is Insulin resistance.