Testing for NHERF1 IHC of a large series of other CNS neoplasms that could arise in any location, including the pineal gland, did not detect microlumens in 22 cases of WHO grade II and III diffuse gliomas, 4 cases of pilocytic astrocytomas and 2 cases of atypical teratoid/rhabdoid tumors [8]. The gene discussed is NHERF1; the disease is pilocytic astrocytoma.