The correlation of expression of adhesion molecules and connexin subtypes is also investigated in human colorectal cancer; a positive correlation between Cx26 and Cx32, but not Cx43 and adhesive proteins in patients without lymph node metastases while a positive association between Cx43 and E-cadherin with lymph node metastases [129]. Here, GJA1 is linked to metastatic malignant neoplasm in the lymph nodes.