A recent report demonstrated that infections of paclitaxel-resistant ovarian cancer cell models with Ad11 and Ad35 oncolytic Ads were significantly more effective.31 Furthermore, pseudotyping with the Ad35 fiber had no effect on in vitro transduction in Chinese Hamster Ovary CHO-CD46 cells in the presence of FX.32 This is thought to be due to an over-riding effect of high affinity binding of Ad35 with CD46, an effect abrogated in CHO wild-type receptor cells lacking CD46. Here, CD46 is linked to infection.