In the present study, we have found that oxidative stress change cell cycling in the bone marrow cells of atherosclerotic mice, as the bone marrow cells in apoE−/− mice were less proliferative than in WT mice (more cells in G0/G1 phase, and less in S phase), suggesting that hypercholesterolemia induces a G0/G1 arrest in bone marrow cells. This evidence concerns the gene APOE and familial hypercholesterolemia.