TP53 and medical procedure: For example, lncRNA-GAS5 expression is significantly downregulated in breast cancer cells, promoting apoptosis.4 The long intergenic non-coding RNA (lincRNA) p21, which contains p53-binding sites for activation during DNA damage, is regarded as an important repressor in the p53-mediated pathway and apoptosis.5 The lncRNAs involved in breast carcinogenesis are still in need of further exploring.