Suppressed tubulin polymerization and increased α-tubulin acetylation contribute to apoptosis of cancer cells.8, 9 To further confirm effects of APOC1P1-3 on acetylation levels of α-tubulin and attenuation of apoptosis, we examined acetylated α-tubulin levels in MCF7 and found that exogenous expression of APOC1P1-3 significantly reduced acetylated α-tubulin (Figure 5d), although the total protein content of α/β-tubulin were unchanged. This evidence concerns the gene APOC1P1 and cancer.