Moreover, this study provided experimental evidence establishing that the expression of miR-1301 can induce BCR-ABL nuclear entrapment and P73 transactivation to enhance IM efficacy in CML cells by downregulating RanGAP1 expression, and this can be used as a therapeutic strategy for CML. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.