KCNK5 and Balkan nephropathy: In this study we have shown that the KCNK5 missense variant (T108P) associated with Balkan Endemic Nephropathy results in a complete loss of function in homomeric TASK-2 channels when expressed in Xenopus oocytes, and that there is impaired trafficking and/or processing of these mutant subunits to the cell surface.