IGHE and allergic respiratory disease: On the one hand it is possible that the severity of AD may depend on the number of different allergen molecules recognized and thus the sum of recognized allergens may play a role as has been recently reported for respiratory allergy to house dust mites: Children with more severe respiratory manifestations (i.e., asthma plus rhinitis) exhibited a broader IgE-recognition towards individual house dust mite allergens than children suffering only from rhinitis [39].