Using the allergen chip [24] with 120 allergen components (S3 Table), 82% of the 179 AD patients showed IgE reactivity to at least one allergen, 85% of the severe and 80% of the moderate AD patients were positive, respectively, and 23% of the 43 patients with SE showed IgE-reactivity to micro-arrayed allergens (Table 2). The gene discussed is IGHE; the disease is Alzheimer disease.