IgE sensitization to genuine cat allergens (rFel d 1 and/or rFel d 4) and house dust mite allergens (nDer p 1 and/or rDer p 2, rDer p 4, rDer p 5, rDer p 7, rDer p 10, rDer p 11, rDer p 14, rDer p 15, rDer p 18, rDer p 21, rDer p 23) also contributed more to IgE sensitization in severe versus moderate AD (Fig 1A). The gene discussed is IGHE; the disease is Alzheimer disease.