IGKV2D-24 and neoplasm: It could also be that when there are higher levels of α7 present in a tumor, the receptors become desensitized to stimulation and are no longer able to be activated to exert their biological function; or alternatively they could become hyperactivated resulting in desensitization in a manner similar to the tumor inhibitory nAChR α4β2 which becomes desensitized in response to constant high affinity stimulation [63].