Our lab has previously shown that in NSCLC, stimulation of α7 nAChR with nicotine results in the activation Src kinase through the recruitment of the β-arrestin-1 scaffolding protein, followed by the subsequent activation of Raf-1 kinase which phosphorylates Rb tumor suppressor protein [34, 35, 38]. Here, CHRNA7 is linked to non-small cell lung carcinoma.