CRP has not only shown to provide a link between the innate and adaptive immunity, but also shown to correlate T-lymphocyte function, stress response, and the degree of hyperglycemia,35 which were important factors associated with the promotion of bacterial growth and the development of postoperative infectious complications.36,37 Therefore, in addition to its predictive value for a clinical infection, CRP may be involved in the modulation of postoperative immune function of patients with gastric cancer. This evidence concerns the gene CRP and gastric cancer.