Although AFP is widely accepted and implemented as a screening method for early stage of HCC, it still has limitations so that the study of new markers for diagnosis and prognosis of early HCC is significant.18 The study investigated the role of FOXO6 in diagnosis and prognosis of cancer to explore the association between FOXO6 and the occurrence and prognosis of HCC. The gene discussed is FOXO6; the disease is hepatocellular carcinoma.