As mutations in the neighboring region (Asp413) result in significantly reduced signaling activity of TLR-3, rs3775291 may prevent glycan moiety of Asp413 from binding to dsRNA or influence its glycosylation, which seems to be able to explain the reduced signaling activity induced by rs3775291.24,25 Again, reduction in signaling activity of TLR-3 causes higher incidence of infections and related diseases. This evidence concerns the gene TLR3 and infection.