The DCE-MRI reflects the permeability (or flow) changes which may result from cytotoxic effects on the hypoxic tumor cells and reduced VEGF production by activation of TH-302, while DW-MRI is an indirect measurement of the cellular consequences that presumably occur following the vasculature change.[30] Interestingly, we observed that the ADC change was significant only in the most sensitive Hs766t tumors, but not in the other two models. Here, VEGFA is linked to neoplasm.