ACTN4 and glomerular disorder: Known glomerular disease genes (S7 Table) were retrieved from the Online Mendelian Inheritance in Man (OMIM) database, which includes genes whose mutations cause glomerular abnormalities in humans, such as NPHS1, ACTN4 and ARHGDIA. The protein-protein interactions between the candidates and the known glomerular disease genes were mapped using HPRD and STRING to deduce possible functions and interactions (Fig 4).