ADAMDEC1 and osteoarthritis: A number of studies and online datasets demonstrate that ADAMDEC1 is not detectable in mature macrophage populations resident in the peritoneum, lung, liver, and adipose tissues and is only moderately expressed in mature splenic macrophages [GSE56711; GDS2982].24,30 However, during inflammation ADAMDEC1 has been reported to be upregulated at sites where it is not constitutively expressed, such as lung, joints, and major blood vessels in pulmonary sarcoidosis,4 osteoarthritis,5 and atherosclerotic plaque instability,3 respectively.