Furthermore, ADAMDEC1 has been reported as under-expressed in MDM and terminal ileal [TI] tissue from patients with quiescent as well as active Crohn’s disease.7,8 We predicted that loss of ADAMDEC1 may increase the host’s susceptibility to bacterial infection and intestinal inflammation resulting in the development of Crohn’s disease. The gene discussed is ADAMDEC1; the disease is Crohn disease.