ADAMDEC1 and colitis: To investigate the potential role of Adamdec1 in bacterial-induced colitis we used the Gram-negative enteric bacterium, C. rodentium, which is capable of inducing a self-limiting colitis in mice.20 Following inoculation with ~ 109 organisms, Adamdec1-/- mice demonstrated significantly greater weight loss [Figure 5a] and mortality [Figure 5b] than the wild type.